★ 2026-09-22 · open.substack.com

The Quest for Universal Flu Vaccines

Modern flu vaccines have an average efficacy of just 40 percent, and they must be revamped each year. How can we make vaccines that are “universal” — both broadly-protective and highly potent?

influenza evolves so quickly that a novel virus emerges each flu season
inactivate viruses with formaldehyde
2026-09-21 · linuxize.com

sudo Cheatsheet

sudo at a glance: running commands as root, credential caching, environment handling, sudoers rule syntax, aliases, Defaults, and logging.

2026-09-20 · qwen.ai

Qwen-Image-2.1: Compact, Efficient, and Unified Image Creation

GITHUB HUGGING FACE MODELSCOPE We are excited to open-source Qwen-Image-2.1, an image model in the Qwen family that balances generation quality, inference efficiency, and cost. Qwen-Image-2.1 unifies text-to-image generation and image editing in a single model, with just 7B…

2026-09-20 · system-design-in-depth.pages.dev

System Design In Depth

Deep system design curriculum — 18 modules, 200 units, 118 architecture diagrams, from-scratch algorithm builds, and curated video walkthroughs for senior engineers.

2026-09-18 · substack.com

Antimony

Three countries mine about 85% of the world's antimony: China, Russia and Tajikistan. The United States imports 91% of what it uses, more than half of it from China, which banned antimony exports to the US in December 2024. The metal goes into ammunition, lead-acid batteries and…

2026-09-18 · wattfactory.substack.com

The Variety Trap

Why Margins Collapse Where Product Variety Explodes, And How Assembly Can Win Them Back

In much of the West, the importance of these close relationships was lost, with competitive bidding and more transactional relationships becoming the norm.
In this model, vertical integration is not about owning everything. It is about owning the layers of the stack where outsourcing would slow learning, limit final integration or affect product performance.
2026-09-18 · substack.com

Barge capacity

One 15-barge tow on the lower Mississippi holds about 875,000 bushels of grain, the load of almost 216 rail cars or 1,000 trucks. Source: USDA Agricultural Marketing Service: https://www.ams.usda.gov/sites/default/files/media/ReliableWaterwaySystem042025.pdf